Linda Papa Selected Research

Ubiquitin Thiolesterase (Ubiquitin Carboxy-Terminal Hydrolase)

1/2022	Evaluation of Glial and Neuronal Blood Biomarkers Compared With Clinical Decision Rules in Assessing the Need for Computed Tomography in Patients With Mild Traumatic Brain Injury.
12/2020	Biomarkers May Predict Unfavorable Neurological Outcome after Mild Traumatic Brain Injury.
1/2019	Evaluating glial and neuronal blood biomarkers GFAP and UCH-L1 as gradients of brain injury in concussive, subconcussive and non-concussive trauma: a prospective cohort study.
1/2017	Neuronal Biomarker Ubiquitin C-Terminal Hydrolase Detects Traumatic Intracranial Lesions on Computed Tomography in Children and Youth with Mild Traumatic Brain Injury.
1/2016	Time Course and Diagnostic Accuracy of Glial and Neuronal Blood Biomarkers GFAP and UCH-L1 in a Large Cohort of Trauma Patients With and Without Mild Traumatic Brain Injury.
5/2012	Serum levels of ubiquitin C-terminal hydrolase distinguish mild traumatic brain injury from trauma controls and are elevated in mild and moderate traumatic brain injury patients with intracranial lesions and neurosurgical intervention.
3/2012	Clinical utility of serum levels of ubiquitin C-terminal hydrolase as a biomarker for severe traumatic brain injury.
1/2010	Ubiquitin C-terminal hydrolase is a novel biomarker in humans for severe traumatic brain injury.

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Linda Papa Research Topics

Disease

25	Traumatic Brain Injuries (Traumatic Brain Injury) 01/2022 - 02/2007
11	Wounds and Injuries (Trauma) 02/2021 - 05/2012
10	Brain Injuries (Brain Injury) 10/2022 - 10/2007
9	Brain Concussion (Cerebral Concussion) 01/2022 - 05/2012
6	Craniocerebral Trauma (Head Injury) 01/2022 - 05/2015
5	Sepsis (Septicemia) 01/2019 - 06/2011
2	Pain (Aches) 08/2022 - 01/2022
2	Hyperglycemia 06/2020 - 03/2011
2	Subarachnoid Hemorrhage (Aneurysmal Subarachnoid Hemorrhage) 01/2018 - 10/2007
1	Body Weight (Weight, Body) 08/2022
1	Lacerations 06/2022
1	Neuroinflammatory Diseases 01/2022
1	Mitochondrial Diseases (Mitochondrial Disease) 01/2022
1	Acute Pain 01/2022
1	Heart Diseases (Heart Disease) 01/2021
1	Heart Arrest (Cardiac Arrest) 01/2021
1	Out-of-Hospital Cardiac Arrest 01/2021
1	Treatment-Resistant Depressive Disorder 01/2021
1	Diabetic Ketoacidosis (Ketoacidosis, Diabetic) 06/2020
1	Intracranial Hemorrhages (Intracranial Hemorrhage) 01/2020
1	Inflammation (Inflammations) 01/2020
1	Atrial Fibrillation 06/2019
1	Diffuse Brain Injuries (Diffuse Brain Injury) 01/2018
1	Closed Head Injuries 01/2017
1	Reinjuries 09/2016
1	Systemic Inflammatory Response Syndrome (Sepsis Syndrome) 05/2016
1	Abscess 02/2015
1	Central Nervous System Diseases (CNS Diseases) 12/2014
1	Nervous System Diseases (Neurological Disorders) 12/2014
1	Hemothorax 01/2014
1	Septic Shock (Toxic Shock Syndrome) 01/2013
1	Pneumonia (Pneumonitis) 06/2011
1	Hypotension (Low Blood Pressure) 03/2011
1	Acidosis 03/2011
1	Seizures (Absence Seizure) 03/2011
1	Cerebrospinal Fluid Leak 10/2007
1	Stroke (Strokes) 10/2007

Drug/Important Bio-Agent (IBA)

30	Biomarkers (Surrogate Marker)IBA 10/2022 - 10/2007
11	Glial Fibrillary Acidic ProteinIBA 01/2022 - 06/2012
8	Ubiquitin Thiolesterase (Ubiquitin Carboxy-Terminal Hydrolase)IBA 01/2022 - 01/2010
5	Carbon DioxideIBA 06/2020 - 01/2013
5	SpectrinIBA 01/2018 - 02/2007
4	Ubiquitin CIBA 01/2014 - 02/2010
3	MicroRNAs (MicroRNA)IBA 01/2020 - 01/2016
2	Ketamine FDA LinkGeneric 06/2022 - 01/2021
2	Lactic Acid (Lactate)FDA LinkGeneric 01/2019 - 01/2013
2	UbiquitinIBA 01/2017 - 01/2017
2	EnzymesIBA 05/2012 - 06/2011
2	CalpainIBA 07/2010 - 02/2007
2	Caspase 3 (Caspase-3)IBA 07/2010 - 02/2007
1	Hydrocodone (Dihydrocodeinone)FDA LinkGeneric 08/2022
1	Acetaminophen (Paracetamol)FDA LinkGeneric 08/2022
1	Fentanyl (Sublimaze)FDA LinkGeneric 08/2022
1	Analgesics (Analgesic Drugs)IBA 08/2022
1	Fatty Acids (Saturated Fatty Acids)IBA 01/2022
1	Opioid Analgesics (Opioids)IBA 01/2022
1	Diltiazem (Cardizem)FDA LinkGeneric 06/2019
1	Anti-Bacterial Agents (Antibiotics)IBA 01/2019
1	cyclo(Arg-Pro) (CI 4)IBA 01/2019
1	Indicators and Reagents (Reagents)IBA 01/2018
1	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA 01/2018
1	HydrolasesIBA 01/2017
1	Neurotransmitter Agents (Neurotransmitter)IBA 12/2014
1	ImmunosorbentsIBA 05/2012
1	Protein CIBA 06/2011
1	Pharmaceutical PreparationsIBA 03/2011
1	Glucose (Dextrose)FDA LinkGeneric 03/2011
1	Proteins (Proteins, Gene)FDA Link 02/2007

Therapy/Procedure

2	Cardiopulmonary Resuscitation (CPR) 01/2021 - 01/2014
1	Anesthesia 06/2022
1	Patient-Controlled Analgesia (Analgesia, Patient Controlled) 01/2022
1	Therapeutics 01/2022
1	Physical Therapy Modalities (Physical Therapy Technique) 12/2021
1	Resuscitation 02/2021
1	Craniotomy 12/2020
1	Debridement 02/2015
1	Sutures (Suture) 02/2013
1	Ventriculostomy 10/2007